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Beclabuvir hydrochloride
CAS No. 958002-36-3
Beclabuvir hydrochloride ( BMS791325;BMS-791325 )
产品货号. M16843 CAS No. 958002-36-3
Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥10287 | 有现货 |
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| 50MG | ￥20898 | 有现货 |
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| 100MG | ￥27540 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Beclabuvir hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively.
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产品描述Beclabuvir (BMS-791325) is a potent allosteric inhibitor of HCV NS5B polymerase with EC50 of 6 and 3 nM for genotype 1b and 1a in FRET assays, respectively; inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of <30 nM; the combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1 in clinical trials.HCV Infection Phase 1 Discontinued
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同义词BMS791325;BMS-791325
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number958002-36-3
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分子量696.30
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分子式C36H46ClN5O5S
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纯度>98% (HPLC)
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溶解度——
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SMILESCN1CC2CCC(C1)N2C(=O)C34CC3C5=C(C=CC(=C5)OC)C6=C(C7=C(N6C4)C=C(C=C7)C(=O)NS(=O)(=O)N(C)C)C8CCCCC8.Cl
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化学全称(4bS,5aR)-12-cyclohexyl-N-(N,N-dimethylsulfamoyl)-3-methoxy-5a-((1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b,5,5a,6-tetrahydrobenzo[3,4]cyclopropa[5,6]azepino[1,2-a]indole-9-carboxamide hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Gentles RG, et al. J Med Chem. 2014 Mar 13;57(5):1855-79.
2. Sims KD, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3496-503.
3. Everson GT, et al. Gastroenterology. 2014 Feb;146(2):420-9.
4. Pelosi LA, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9.
2. Sims KD, et al. Antimicrob Agents Chemother. 2014 Jun;58(6):3496-503.
3. Everson GT, et al. Gastroenterology. 2014 Feb;146(2):420-9.
4. Pelosi LA, et al. Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9.
产品手册
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